Zyrab-D is contraindicated in patients with known hypersensitivity to rabeprazole, substituted benzimidazole domperidone or any component of the formulation. Rabeprazole belong to the class of medications known as proton-pump inhibitors(PPIs). It is also used to treat heartburn, Gastro-esophagea reflux disease (acid reflux) and stomach ulcer. Domperidone is a antagonist with anti-emetic properties. antiemetic activity is due to the blockade of receptors in the chemoreceptor trigger zone (CTZ). It is increase lower esophageal pressure, improve duodenal motility, and accelerate gastric emptying.